The book picks up the story of Kamala Khan, a 16-year-old Pakistani-American who lives in Jersey City and idolizes Carol Danvers (a.k.a., Captain Marvel). Turned into an Inhuman by (non-nerds, bear with me here) Black Bolt's detonation of a Terrigen Bomb in the "Infinity" story, she now finds herself with superpowers, and takes on the name "Ms. Marvel". Now, she has to figure out how to deal with her dreams of being a real superhero coming true, not to mention how it will fit into the rest of her already complicated life.
My description really doesn't do this book justice.
The writing is great, and the art is a lot more interesting than your standard Big 2 superhero book (although I understand the artist changes after Issue #5, the last one in this collection). The origin/coming-of-age story could have been terribly cliched, as could have the cultural and religious aspects, but Wilson handles it all quite deftly.
Do yourself a favor and go check this one out. It's a fresh take on a title/character that has been around for quite a while, and you really don't even need any background in the larger Marvel comic universe to pick this one up.